Discovery of epigenetic links in cell-fate decisions of adult stem cells paves way for new osteoporosis treatments

ScienceDaily (July 9, 2012) ? The ability to control whether certain stem cells ultimately become bone cells holds great promise for regenerative medicine and potential therapies aimed at treating metabolic bone diseases.

Now, UCLA School of Dentistry professor and leading cancer scientist Dr. Cun-Yu Wang and his research team have made a significant breakthrough in that direction. The scientists have discovered two key epigenetic regulating genes that govern the cell-fate determination of human bone marrow stem cells.

Wang's new research is featured on the cover of the July 6 issue of Cell Stem Cell, the affiliated journal of the International Society for Stem Cell Research.

The groundbreaking study grew out of Wang's desire to better understand the epigenetic regulation of stem cell differentiation, in which the structure of genes is modified while the sequence of the DNA is not. He and his team found that KDM4B and KDM6B, two gene-activating enzymes, can promote stem cells' differentiation into bone cells by removing methyl markers from histone proteins. This process occurs through the activation of certain genes favoring a commitment to one lineage and the concurrent deactivation of genes favoring other lineages.

The findings imply that chemical manipulation of these gene-activating enzymes may allow stem cells to differentiate specifically into bone cells, while inhibiting their differentiation into fat cells. The group's research could pave the way toward identifying potential therapeutic targets for stem cell-mediated regenerative medicine, as well as the treatment of bone disorders like osteoporosis, the most common type of metabolic bone disease.

"Through our recent discoveries on the lineage decisions of human bone marrow stem cells, we may be more effective in utilizing these stem cells for regenerative medicine for bone diseases such as osteoporosis, as well as for bone reconstruction," Wang said. "However, while we know certain genes must be turned on in order for the cells to become bone-forming cells, as opposed to fat cells, we have only a few clues as to how those genes are switched on."

The research group, through its study of aging mice, found that the two enzymes KDM4B and KDM6B could specifically activate genes that promote stem cell differentiation toward bone, while blocking the route toward fat.

"Interestingly, in our aged mice, as well as osteoporotic mice, we observed a higher amount of silencing histone methyl groups which were normally removed by the enzymes KDM4B and KDM6B in young and healthier mice," Wang said. "And since these enzymes can be easily modified chemically, they may become potential therapeutic targets in tissue regeneration and treatment for osteoporosis."

"The discovery that Dr. Wang and his team have made has considerable implications for craniofacial bone regeneration and treatment for osteoporosis," said Dr. No-Hee Park, dean of the UCLA School of Dentistry. "As a large portion of our population reaches an age where osteoporosis and gum disease could be major health problems, advancements in aging-related treatment are very valuable."

Professor Wang holds the No-Hee Park Endowed Chair in Dentistry at the UCLA School of Dentistry, where he is also chair of the division of oral biology and medicine and the associate dean for graduate studies.

The study was supported by grants from the National Institute of Dental and Craniofacial Research.

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Story Source:

The above story is reprinted from materials provided by University of California - Los Angeles. The original article was written by Brianna Deane.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Ling Ye, Zhipeng Fan, Bo Yu, Jia Chang, Khalid Al?Hezaimi, Xuedong Zhou, No-Hee Park, Cun-Yu Wang. Histone Demethylases KDM4B and KDM6B Promotes Osteogenic Differentiation of Human MSCs. Cell Stem Cell, 2012; 11 (1): 50 DOI: 10.1016/j.stem.2012.04.009

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/IDv_hrMqovI/120709093229.htm

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Dracula, The Mummy and six other horror classics coming in a Blu-ray set October 2nd (video)

Universal Classic Monsters: The Essential Collection will arrive on shelves October 2nd, and pack eight classic horror movies, all restored so they can be seen in the highest quality possible. Among the releases is Creature from the Black Lagoon restored for Blu-ray 3D (yes, like Dial M for Murder it was originally shot and released in 3D back in 1954), as well as Dracula, Frankenstein, The Mummy, The Invisible Man, Bride of Frankenstein, The Wolf Man and Phantom of the Opera. This is all a part of the ongoing Universal centennial celebration that's seeing its vaults unleash many of our favorites for the first time in high definition. After the break you can check out a featurette detailing the process undertaken to prep Dracula for Blu-ray release, as well as a press release with details on all of the flicks and which extras are included for each movie. Of course, the downside of a pack like this is that it's pricey -- the MSRP is $160, but it's available for preorder on Amazon currently priced at $112.

Continue reading Dracula, The Mummy and six other horror classics coming in a Blu-ray set October 2nd (video)

Dracula, The Mummy and six other horror classics coming in a Blu-ray set October 2nd (video) originally appeared on Engadget on Sun, 08 Jul 2012 17:47:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/07/08/dracula-the-mummy-frankenstein-black-lagoon-universal-blu-ray/

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Monster Inspiration

First it was cables, then Monster teamed with Dr. Dre to create the Beats lineup of headphones. Now, with a plethora of Beats headphones and speaker systems on the market, Monster's focusing on its own brand a bit more. The new Monster Inspiration headphones have a definite Beats feel to them in design and also in sound signature, although they have no actual association with Beats Audio. The $279.95 (list) headphones aren't ideal for audiophiles seeking flat response, but fans of deep bass and bright highs won't be disappointed. The Inspiration ?is a powerful, distortion-free pair with a highly tweaked frequency response?and comes with some useful accessories to boot.

Design
Before we proceed, let's note that PCMag is reviewing the passive headphone version of the Inspiration, not the powered, noise-cancelling model. Eventually, we hope to check that pair out as well, but the Inspiration does provide a reasonable amount of passive noise reduction without any battery-powered circuitry.

Monster's Inspiration headphones are sturdy-looking, with comfortable rectangular ear cups that are more circumaural (around-the-ear) than supra-aural (on-the-ear). Even so, the cups somehow feel like a hybrid of the two, since the pads aren't quite big enough to make a full seal around the ear, but are too large to rest only on the ear.

As with many Monster-designed products, the headphones come with some visual flair, such as the removable, replaceable headband. Our all-black pair came with the standard black leather headband (with the Inspiration logo embossed on it), which easily snaps out. One extra headband ships with each pair. Ours was a shiny black reptile leather print?definitely an eye-catcher, but definitely not for everyone. More headband styles will be on sale soon, though pricing may vary.

No one will knock Monster for skimping on accessories. First off, the linguini-esque cable, which can fit into either ear's 3.5mm jack along the lower panel of the rectangular earcups, is removable. Right there, you get some added value, since the cable, not the drivers, is usually the first thing to wear out on a pair of headphones. Normally, even with a removable cable, if it's faulty, you'd still have to spend money to replace it, but Monster provides you with three cables total. This is one of the more impressive inclusions we've seen in the headphone accessory department.

Granted, each cable is a slightly different style. You get an iPhone cable with volume control, mic, and remote button; a universal phone cable that also still works with iPhone but lacks volume controls, and a regular audio cable with no phone or volume controls at all. So technically, whichever you choose to start with will need to be purchased again if you wish to replace it exactly. But with two phone-friendly options, my guess is most users will tough it out, and by the time you burn through two of them, you'll probably be ready for a new headphone pair?though that could be several years from now, if you treat them well.

Also included: a plush, zip-up protective pouch for the headphones to fold into, and a cleaning cloth so you can keep your Inspiration looking shiny and new. The lack of any 1/4-inch or airplane adapters is a bit of an oversight, but one we're wiling to overlook since they're relatively cheap and easy to find (Radio Shack or Best Buy should do the trick), and the inclusion of three cables is much more useful.

Performance
One thing Monster is known for with the Beats line is some serious tweaking of the lows and highs. The Beats by Dr. Dre from Monster ($349.95, 4 stars) offer powerful audio, with significantly boosted bass and tweaked treble. While the Monster Inspiration doesn't sound identical, audiophiles seeking flat response headphones should probably look in a different direction, as the basic characteristics of the Beats line are represented here, as well: deep bass meets bright highs. It actually sounds, for lack of a better term, exciting, but when you compare back-and-forth with the Bowers & Wilkins P3 ($199.99, 4 stars), you get a sense of just how much brighter and crisper the Inspiration is, and that this isn't necessarily accurate reproduction. The Inspiration also provides more power, and far deeper lows, while the P3 ?seems to focus more on the mid-range frequencies.

There's no distortion to speak of on deep bass tracks. The Knife's "Silent Shout," which has extremely deep low frequencies, is still conveyed distortion-free even at top volumes?not that anyone should be listening at these unsafe levels. The matching boosts in the high frequencies help keep things from ever sounding too muddy, but the peaks at both ends of the frequency range mean the low-mids and hi-mids can sometimes sound a bit weak and neglected. This sound signature makes the two most prominent aspects of most pop and hip-hop mixes?the beat and the vocals?step to the forefront. Even at moderate levels, Jay Z and Kanye West's "No Church in the Wild" feels as if it's coming through a powerful club sound system.

One genre the Inspiration has a little bit of trouble with is classical music recordings, which tend to focus more on dynamics, and rarely feature booming bass or tweaked highs. The result, as can be heard on tracks like John Adams' modern classical piece, "The Chairman Dances," is not appalling, it just seems a bit removed from what the actual room probably sounded like during the recording. Low frequencies from the lower register strings have an exaggerated resonance that doesn't sound bad, but doesn't sound natural either. The boosted highs have a less negative effect, adding a crispness to the attack of brass instruments and higher-register strings and percussion. The overall sound could easily appeal to some listeners, but it's a very sculpted sound that is both brighter and deeper than what the conductor or mastering engineer would have heard.

If there were only one proper way to make quality headphones, they'd all sound more or less the same. Audiophiles may thumb their noses at the Boses and Monsters of the world, both of which are famous for tweaking the frequency response rather than delivering a flat, more transparent audio experience. The Inspiration offers distortion-free, powerful audio with some serious depth on the low frequencies and a significant boost to the highs. This sound works particularly well for modern pop music, as well as hip-hop, rock, and other modern mixes. But it's not for purists, and it's more or less up to you to decide where your tastes fall in this regard.

If you're looking for something a bit more focused on flat response, the Shure SRH1440 ($399.99, 4 stars) is an ideal pair for critical listening and mastering scenarios?it has a focus on the mids and highs that is a bit less exaggerated than the Inspiration's, and paired with far less low-end boom. If all of these headphones are well out of your range, but you want headphones?not in-canal earphones?consider the Senta-40 Wood Headphones by C. Crane ($59.95, 3.5 stars), which doesn't sound jaw-droppingly amazing, but at $60, sounds far better than you'd expect for the price. If you can audition a pair, it's worth seeing if the Inspiration is right for you. The lack of distortion and inclusion of extra cables are both positives?and if you like your highs extra crispy and favor a bit more push from the bass, the Inspiration should definitely be on your radar.

More Headphone Reviews:
??? Monster Inspiration
??? Moshi Vortex Pro
??? Philips CitiScape Uptown
??? Sennheiser RS 220
??? Sennheiser MM 100
?? more

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/YHhZuXpcgEU/0,2817,2406555,00.asp

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Switched On: The Netbook Legacy

Each week Ross Rubin contributes Switched On, a column about consumer technology.

In describing Toshiba's decision to exit the U.S. netbook market, Engadget eulogized that it was "a sad day for those who like their computers tiny." Toshiba, a pioneer in the ultraportable market with the Libretto and Portege, produced what were among the best-regarded netbooks despite entering the market late. Indeed, even with the many aspersions cast upon netbooks by one-time friends (such as Dell and Toshiba) and perennial foes (such as Apple) alike, the accelerating exit of netbooks will leave a void in the marketplace. Many consumers saw the value of a 10-inch device with an integrated keyboard that can run Windows apps, available new in some configurations for $250 or less.

And yet, even as major PC companies flee the field, accessory makers such as Logitech and Zagg, as well as overfunded Kickstarter projects such as Brydge or Incase's Origami case, present new ways to unite the iPad with its most conspicuous missing component: the keyboard. It seems incongruous that a 10-inch netbook is undesirable whereas a 10-inch tablet paired with a keyboard for which it is not optimized is. And most keyboards for the iPad use Bluetooth, the use of which is verboten on flights (even as WiFi has been approved).

Continue reading Switched On: The Netbook Legacy

Switched On: The Netbook Legacy originally appeared on Engadget on Sun, 08 Jul 2012 17:30:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2012/07/08/the-netbook-legacy/

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New World Heritage Site a Haven for African Wildlife

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Source: http://news.yahoo.com/world-heritage-haven-african-wildlife-160625364.html

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Bullbear Buffett Stock Investing Notes: My 18 points guide to ...

My 18 points guide to Successfully compounding your money in Stocks

1. Be a good stock picker.??
2. Think as a business owner.
3. Always look at value rather than the price.? Do the homework.
4. Buy and hold is alright for selected stocks.
5. Compounding is your friend, get this to work the magic for you.
6. Mr. Market is there to be taken advantage of.? Do not be the sucker instead.? BFS;STS.
7. Always buy a lot when the price is low.? Doing so locks in a higher potential return and minimise the potential loss.? But then, if you have confidence in your stock picking, you would have picked a winner - it is only how much return it will deliver over time.
8. Never buy when the stock is overpriced.? Not observing this rule will result in loss in your investing.? This strategy is critical as it protects against loss.
9. It is alright to buy when the selected stock is at a fair price.
10. Phasing in or dollar cost averaging is safe for such stocks during a downtrend, unless the the price is still obviously too high.
11. Do not time the market for such or any stocks.?? Timing can increase returns and similarly harms the returns from your investment. It is impossible to predict the short term volatility of the stock, therefore, it is better to bet on the long-term business prospect of the company which is more predictable.?
12. By keeping to the above strategy, the returns will be delivered through the growth of the company's business.?
13. So, when do you sell the stock?? Almost never, as long as the fundamentals remain sound and the future prospects intact. ???
14. The downside risk is protected through only buying when the price is low or fairly priced.? Therefore, when the price is trending downwards and when it is obviously below intrinsic value, do not harm your portfolio by selling to "protect your gains" or "to minimise your loss."? Instead, you should be brave and courageous (this can be very difficult for those not properly wired)? to add more to your portfolio through dollar cost averaging or phasing in your new purchases.? This strategy is very safe for selected high quality stocks as long as you are confident and know your valuation.? It has the same effect of averaging down the cost of your purchase price.? However, unlike selling your shares to do so, buying more below intrinsic value ensures that your money will always be invested to capture the long term returns offered by the business of the selected stock.
15. Tactical dynamic asset allocation or rebalancing based on valuation can be employed but this sounds easier than is practical, except in extreme market situations.? Tactical dynamic asset allocation or rebalancing involves selling at the right price and buying at the right price based on valuation.? Assuming you can get your buying and your selling correct 80% of the time;, to get both of them right for a profitable transaction is only slightly better than chance (80% x 80% = 64%).? Except for the extremes of the market, for most (perhaps, almost all of the time), for such stocks, it is better to stay invested (buy, hold, accumulate more) for the long haul.
16. Sell urgently when the company business fundamental has deteriorated irreversibly. (Reminder:??Transmile)
17. You may also wish to sell? should the growth of the company has obviously slowed and you can reinvest into another company with greater growth potential of similar quality.? However, unlike point 14, you can do so leisurely.
18. In conclusion, a critical key to successful investing is in your stock picking ability.? To be able to do so, you will need to acquire the following skills:

• To formulate an investing philosophy and strategy suitable for your investing time horizon, risk tolerance profile and investment objectives.
• The knowledge to value the business of the company.??
• The discipline to always focus on value.
• The willingness to do your homework diligently.
• A good grasp of behavioural finance to understand your internal and external responses to the price fluctuations of the stock in the stock market.
• A good rational thinking regarding the risks (dangers) and rewards (opportunities) generated by the price fluctuations of the stock in the stock market.

Is it not true, that?the really big fortunes from common stocks have been garnered by those?

• who?made a?substantial commitment?in the?early years?of a company in whose?future they had great confidence?and?
• who?held their original shares unwaveringly?while they increased 10-fold or 100-fold or more in value?

The answer is?"Yes." ?

Source: http://myinvestingnotes.blogspot.com/2012/07/my-18-points-guide-to-successfully.html

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Presbyterian church rejects same-sex marriage

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Source: http://news.yahoo.com/presbyterian-church-rejects-same-sex-marriage-130033562.html

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